HSP90 inhibition without heat shock response
نویسندگان
چکیده
منابع مشابه
Inhibition of Heat Shock Protein Hsp90 Reverses Chemotherapy Resistance of Ovarian Cancer
Aim: To explore the mechanism of Hsp90 in chemotherapy resistance of paclitaxel in ovarian cancer. Methods: MTT were used to detect the effect of BIIB021 on ovarian cancer resistant cells (A2780/Taxol) to paclitaxel, half inhibitory concentration and flow cytometry were used to detect apoptosis. Western blotting was performed to detect MRP1, MDR1, Bcl2 and Survivin protein expression in A2780 a...
متن کاملInhibition of Heat Shock Protein 70 and 90 (Hsp70 And Hsp90) in Target Spesific Cancer Treatment
Volume 3 • Issue 2 • 1000e109 Adv Tech Biol Med ISSN: 2379-1764 ATBM, an open access journal Hsp70 (70 kDa) and Hsp90 (90 kDa) are important members of the chaperone protein family. They are over-expressed in a wide range of tumor types (both solid tumors and hematological malignancies), and play essential roles in apoptosis, cell proliferation, metastases, angiogenesis, and invasion pathways i...
متن کاملThe heat-shock response.
PERSPECTIVES AND SUMMARY .............................................................. 1151 CHARACTERIZATION OF THE RESPONSE .................................................. 1153 Comparison: Different Organisms and Stages of Development ........................... 1153 The Proteins Induced by Heat .................................................................. 1155 RNAs Induced by Heat .....
متن کاملTargeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors.
Novel classes of anticancer drugs, including proteasome inhibitors and Hsp90 inhibitors, potently induce heat shock proteins (Hsps). Because Hsps show antiapoptotic activities, we suggested that suppression of such induction may sensitize cancer cells to these drugs. Here, we knocked out the major heat shock transcription factor HSF-1 in several cancer cell lines using small interfering RNA and...
متن کاملP-Glycoprotein-mediated resistance to Hsp90-directed therapy is eclipsed by the heat shock response.
Despite studies that show the antitumor activity of Hsp90 inhibitors, such as geldanamycin (GA) and its derivative 17-allylamino-demethoxygeldanamycin (17-AAG), recent reports indicate that these inhibitors lack significant single-agent clinical activity. Resistance to Hsp90 inhibitors has been previously linked to expression of P-glycoprotein (P-gp) and the multidrug resistant (MDR) phenotype....
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ژورنال
عنوان ژورنال: Blood
سال: 2018
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2018-05-850271